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[P3–251]: BLOOD TAU LEVEL AS A MARKER FOR ALZHEIMER's DISEASE AND ITS CORRELATION WITH TOTAL TAU DEPOSITION IN THE BRAIN
Author(s) -
Yadav Saroj Kumar,
Dey Aparajit Ballav
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1465
Subject(s) - tau protein , posterior cingulate , cognition , dementia , cognitive decline , memory clinic , medicine , cortex (anatomy) , parkinsonism , correlation , disease , psychology , alzheimer's disease , neuroscience , pathology , geometry , mathematics
Background: Tau deposition in cortex has been shown to be closely related to cognition, predominantly memory decline, in post-mortem studies of both aging and AD. Blood levels of Tau as a marker of AD and its correlation with deposition in cortex is studied. Methods:Patients attending Memory Clinic of the Department of Geriatric Medicine were evaluated for their cognitive symptoms with MMSE scoring systems. Dementia related to Vascular, Metabolic, Depression, other degenerative causes (eg. Parkinsonism) were excluded. A total of 85 selected subjects underwent further cognitive evaluation in the form of CDR, imaging evaluation that included MRI scan and PET scan[ 18 FDG and 18F T807 (TAU)].Blood samples were analysed for tau and phosphorylated-tau proteins. Study subjects were divided into 3 categories: Normal Controls, Mild Cognitive Impairment and Probable AD (Based on NINDSADRDA criteria). Results: Mean 18F T807 (TAU) binding as measeured by SUVmax of different neocortical regions among the groups showed an increase binding with decrease in cognition but with notable overlap among the groups. Binding, particularly in posterior cingulate area, of the Tau showed increase binding which was statistically significant (p<0.05).Blood markers in the form of serum tau and phosphorylated tau was evaluated among the groups which showed an increasing trend with decline in the cognition and the values were statistically significant. Conclusions: Blood levels of tau and phosphorylated tau proteins can be used as a surrogate marker for memory decline.