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[P3–244]: SESTRIN LEVELS IN PATIENTS DIAGNOSED WITH MILD COGNITIVE IMPAIRMENT AND ALZHEIMER's DISEASE: A POTENTIAL MARKER
Author(s) -
Rai Nitish,
Singh Amrendra Pratap,
Shekhar Shashank,
Yadav Yudhishthir,
Dey Aparajit B.,
Dey Sharmistha
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1457
Subject(s) - western blot , peripheral blood mononuclear cell , oxidative stress , dementia , medicine , autophagy , alzheimer's disease , endoplasmic reticulum , endocrinology , disease , pathology , biology , in vitro , apoptosis , biochemistry , gene
Figure 1. Floating bar diagramwith line at mean showing the concentration of serum sesn2 (A) and sesn1 (B) in elderly control (n1⁄4 60), MCI (n1⁄4 27), and AD (n 1⁄4 41) subjects. These serum concentrations, estimated by SPR technology, showed increased levels of sesn2 in MCI and AD but not in elderly controls (p < 0.0001) while there was no significant difference for sesn1 in elderly controls, MCI, and AD. Nicholas J. Ashton, Alejo J. Nevado-Holgado, Steven Lynham, Malcolm Ward, Veer Bala Gupta, Pratishtha Chatterjee, Kathryn Gooze, Eugene Hone, Steve Pedrini, Ashley I. Bush, Christopher C. Rowe, Victor L. L. Villemagne, David Ames, Colin L. Masters, Dag Aarsland, Simon Lovestone, Ralph N. Martins, Abdul Hye, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom; King’s College London, London, United Kingdom; University of Oxford, Oxford, United Kingdom; Proteome Sciences plc, London, United Kingdom; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia; Cooperative Research Centre for Mental Health, Melbourne, Australia; KaRa Institute of Neurological Diseases, Sydney, Australia; Macquarie University, Sydney, Australia; KaRa Institute of Neurological Diseases, Melbourne, Australia; Edith Cowan University of Medical Sciences, Joondalup, Australia; Edith Cowan University, Perth, Australia; AIBL Research Group, Perth andMelbourne, Australia; The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia; The University of Melbourne, Melbourne, Australia; University of Melbourne, Melbourne, Australia; Austin Health, Melbourne, Australia; The University of Melbourne, Parkville, Australia; University of Melbourne, Austin Health, Melbourne, Australia; National Ageing Research Institute, Melbourne, Australia; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden; Stavanger University Hospital, Stavanger, Norway; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia; Australian Alzheimer’s Research Foundation, Perth, Australia; Sir James McCusker Alzheimer’s Disease Research Unit (Hollywood Private Hospital), Perth, Australia; Edith Cowan University, Joondalup, Australia; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, United Kingdom. Contact e-mail: nicholas.1.ashton@kcl.ac.uk