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[P3–225]: SYSTEMATIC REVIEW OF ASSOCIATIONS BETWEEN BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA AND CYTOKINES
Author(s) -
Harrison Fleur,
Aerts Liesbeth,
Seeher Katrin M.,
Lloyd Andrew,
Trollor Julian N.,
Guastella Adam,
Brodaty Henry
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1438
Subject(s) - apathy , dementia , neurocognitive , psycinfo , psychosis , medicine , clinical psychology , psychiatry , population , association (psychology) , cognition , psychology , medline , disease , environmental health , political science , law , psychotherapist
actual mechanism in AD pathogenesis is poorly understood. Methods: In this cross-sectional comparison, we examined the plasma LDL lipoprotein profiles of clinically classified healthy control and Alzheimer’s affected individuals from the Australian Imaging, Biomarker and Lifestyle (AIBL) study. These individuals had also undergone several other characterisations including PiBPET imaging for determination of brain amyloid load. Results: The data indicate that the APOE ε4 participants tended to have higher median levels of larger plasma LDL species while also being associated with higher amyloid load. These individuals also showed high variations in large LDL levels, indicating altered regulation of LDL metabolism. We also identified a possible association with LDL levels in non-ε4 participants and neocortical amyloid load, suggesting that plasma LDL is involved with AD pathogenesis. Conclusions:APOE ε4 influences the levels of plasma LDL species and is associated with higher amyloid load in the brain. The larger LDL species show positive association with higher brain amyloid load, supporting a metabolic link between brain and periphery.