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[P3–207]: THE ENDOPHENOTYPE ASSOCIATION SCORE IN EARLY ALZHEIMER's DISEASE (EASE‐AD): DISCOVERING NOVEL BLOOD AND BRAIN METABOLITE SIGNATURES OF PATHOLOGY AND PROGRESSION
Author(s) -
Varma Vijay R.,
Oommenn Anup,
Varma Sudhir,
Casanova Ramon,
An Yang,
Andrews Ryan,
O'Brien Richard,
Pletnikova Olga,
Troncoso Juan C.,
LegidoQuigley Cristina,
Thambisetty Madhav
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1420
Subject(s) - endophenotype , dementia , medicine , neuroimaging , alzheimer's disease , atrophy , neurology , pathology , metabolite , oncology , disease , cognition , physiology , psychology , neuroscience , psychiatry
aged 45 years who had gradable OCT images and were free from dementia and stroke at baseline. RNFL thickness was measured peripapillary in 3,585 persons, and GCL and IPL thicknesses were measured perimacular in 3,273 persons. Follow-up for dementia and stroke was complete till January 2015. Associations between retinal sublayer thickness and dementia and stroke were examined using Cox proportional hazards models, adjusting for age, sex, subcohort, axial length of the eye, education, and cardiovascular risk factors. Results:Mean age was 68.9 years (standard deviation: 10.0). During 13315 person-years of follow-up (mean: 3.7 years), 88 persons developed dementia of whom 57 were Alzheimer’s disease. Thinner RNFL at baseline was significantly associated with an increased risk of developing dementia, adjusted hazard ratio (HR) per standard deviation (SD) decrease in RNFL: 1.29 (95% confidence interval (CI): 1.06-1.56). For Alzheimer’s disease, the adjusted HR was 1.31 (1.04-1.65) per SD decrease in RNFL. No association was found between GCL and IPL with the risk of dementia. None of the retinal sublayer thicknesses were related to the risk of stroke. Conclusions: Thinner RNFL at baseline was associated with an increased risk of dementia, particularly AD. These findings suggest that thinner RNFL may thus be a novel risk factor for overall dementia, and specifically for AD.