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[P3–199]: ABNORMALITIES OF CORTICAL NEURAL SYNCHRONIZATION MECHANISMS IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT DUE TO ALZHEIMER's AND PARKINSON's DISEASES: AN EEG STUDY
Author(s) -
Lizio Roberta,
Del Percio Claudio,
Cordone Susanna,
Lopez Susanna,
Soricelli Andrea,
Ferri Raffaele,
Nobili Flavio,
Famà Francesco,
Aarsland Dag,
Orzi Francesco,
Buttinelli Carla,
Giubilei Franco,
Onofrj Marco,
Stocchi Fabrizio,
Stirpe Paola,
Fuhr Peter,
Gschwandtner Ute,
Ransmayr Gerhard,
Garn Heinrich,
Pievani Michela,
Frisoni Giovanni B.,
D'Antonio Fabrizia,
Lena Carlo,
Başar Erol,
Yener Görsev,
Bonanni Laura,
De Pandis Francesca,
Babiloni Claudio
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1411
Subject(s) - electroencephalography , receiver operating characteristic , cognitive impairment , medicine , audiology , alpha (finance) , cognition , pathological , neuroscience , disease , psychology , cardiology , surgery , construct validity , patient satisfaction
with the results of the neurochemical dementia diagnostics (NDD) biomarkers in all cases (Ab1-42, Ab42/40 ratio (IBL International), Tau, and pTau181 (Fujirebio Europe, Ghent, Belgium)). Results: Intra-assay coefficients of variation were 1.2% and 0.8% for two CSF control samples (eight repetitions of each, sample dilution 1:2). Compared to the non-demented Controls (82.76 6.0 pg/mL), MCI-AD subjects and ADD patients had significantly increased concentrations of the CSF toxic Ab oligomers (88.4 6 4.5 pg/mL, p1⁄40.027, and 88.9 6 3.7 pg/mL, p1⁄40.016, respectively); there was no significant differences between MCI-AD and ADD subjects (p>0.9). The results remained significant after adjusting for age and sex of the subjects. Neither age nor sex (either unadjusted or adjusted for the concentrations of oligomeric Ab) significantly influenced the concentrations of oligomeric Ab. Conclusions: In line with amyloid hypothesis of AD, the results of this pilot study suggest increased concentrations of oligomeric Ab in the CSF of AD patients, already at the stage of MCI. Further studies are necessary to confirm our findings.