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[P1–074]: PRECLINICAL DISCOVERY AND DEVELOPMENT OF MEDI1814, A MONOCLONAL ANTIBODY SELECTIVELY TARGETING BETA‐AMYLOID 42 (Aβ42)
Author(s) -
Billinton Andy,
Newton Phil,
Lloyd Chris,
Groves Maria,
Welsh Fraser,
Bogstedt Anna,
Eketjall Susanna,
McFarlane Mary,
Perkinton Michael,
Narwal Rajesh,
Tan Keith,
Dudley Amanda,
Vaughan Tristan,
Chessell Iain
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.141
Subject(s) - in vivo , monoclonal antibody , peptide , antibody , in vitro , phage display , chemistry , microbiology and biotechnology , peptide library , pharmacology , biochemistry , biology , immunology , peptide sequence , gene
analysis of cognition collaboration’ (OA-Cog) aims to identify the most efficient cognitive measurement and analysis technique for cognition data and dementia in randomised controlled trials including patients with or at risk of vascular dementia or Alzheimer’s disease. Methods: Chief investigators of randomised controlled trials with cognitive outcome assessments are asked to share individual patient data from their trials. Variables requested include baseline prognostic factors, treatment group, cognitive measures (e.g. Mini Mental State Examination (MMSE), Alzheimer’s Disease Assessment Scale cognitive sub-score (ADAS-cog)) and other outcome measures (e.g. death, dementia). Shared trial data are merged into a single dataset and analysed using various endpoints (e.g. mean MMSE score at end of trial, MMSE score as a gradient over time) and statistical methods (e.g. Wilcoxon rank-sum test, repeated measures ANOVA) in order to identify which is the most efficient approach. Methods for dealing with missing data and, in particular, the case of missing data due to death will be addressed; currently, such patients are often ignored from analyses. Results: As of 23 December 2016, data from 32 clinical trials have been shared with the collaboration. Some of these trials have more than two treatment arms, so 50 datasets are available with a total of 120,576 participants. Conclusions:Optimising the design and analysis of cognition trials will allow future trials to detect smaller but still clinically important effects, and/or have smaller sample sizes than current trials.