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[P3–171]: ACUTE, TRANSIENT INCREASE IN SECRETION OF NEURODEGENERATION BIOMARKERS AFTER IRRADIATION OF HUMAN CORTICAL NEURONS
Author(s) -
Bergström Petra,
Satir Tugce Munise,
Nazir Faisal Hayat,
Fernström Erik,
Blennow Kaj,
Agholme Lotta,
Kalm Marie,
Zetterberg Henrik
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1383
Subject(s) - radiation therapy , secretion , neurodegeneration , medicine , acute radiation syndrome , irradiation , human brain , ionizing radiation , cerebrospinal fluid , neuroscience , pathology , biology , microbiology and biotechnology , stem cell , disease , physics , haematopoiesis , nuclear physics
both produce and uptake beta-amyloid. AD astrocytes secrete significantly higher amounts of the 1-42 form and show an elevated 1-42/1-40 ratio as compared to controls, but respond well to treatment with gamma-secretase inhibitor DAPT. Conclusions:Our data show that pathological findings commonly seen in AD patients are recapitulated in the iPSC-derived astrocytes. Thus, these cells offer a valuable tool for studying the disease mechanisms and for drug screening and testing novel therapeutic approaches in a cell-type specific manner.