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[P3–140]: GENDER‐BASED DIFFERENCE IN SEROTONIN NEUROTRANSMITTER IN DORSAL RAPHE OF POSTMORTEM HUMAN AND NONHUMAN PRIMATES
Author(s) -
Reddy Arubala P.,
Reddy Hemachandra
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1351
Subject(s) - dorsal raphe nucleus , microarray , serotonin , biology , microarray analysis techniques , depression (economics) , context (archaeology) , raphe nuclei , psychology , medicine , gene expression , neuroscience , endocrinology , serotonergic , gene , genetics , receptor , macroeconomics , economics , paleontology
the variance in hippocampus volume. The first latent score (X1), explaining 27% of variance, displayed negative contributions of age, bmi and WML together with positive contributions of education, GM volume, (T-) lymphocytes and T-cytotoxic cells (Fig 2). The second latent score (X2), explaining 4% variance, showed negative contributions of (B-) lymphocytes, natural killer (NK) cells and all T-cells, together with positive contributions of (typical) monocytes, while the third score (X3), explaining 3% variance, included negative contributions of education, SES, granuloand neutrophils and positive contributions of lymphocytes, Band T-lymphocytes, B, NK and T-helper cells. Conclusions: In this large cross-sectional study, immune T-cell populations contributed to a latent score that predicted hippocampus volume, together with higher education and GM volume and lower age, bmi, andWML. Further differential associations of specific cell-subpopulations with hippocampus volume might be explained by effects of acute and chronic immune status.