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[P3–129]: EARLY AND LATE NEUROINFLAMMATORY EVENTS AS ALZHEIMER's DISEASE PATHOLOGY EVOLVES IN DOWN SYNDROME INDIVIDUALS
Author(s) -
Aguilar Lisi Flores,
Iulita M. Florencia,
Wisniewski Thomas,
Busciglio Jorge A.,
Cuello A. Claudio
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1340
Subject(s) - neuroinflammation , neuropathology , pathogenesis , disease , inflammasome , dementia , medicine , genetically modified mouse , pathology , down syndrome , inflammation , neuroscience , immunology , psychology , transgene , biology , psychiatry , gene , genetics
showed that blast generated distributed force loading on the head and diffuse shear stress in brain. Impact produced point loading with seven-fold greater peak shear stress in brain before onset of gross head motion. Conclusions: We conclude that fast-acting, high-amplitude cortical shear stresses trigger concussive signs, whereas longer duration, lower amplitude forces induce structural damage and sequelae. Closed-head impact can induce TBI and trigger antecedent CTE pathologies independent of concussion.