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[P3–067]: DEVELOPMENT OF HIGHLY SENSITIVE MSD ASSAYS FOR THE DETECTION OF ANTI‐AMYLOID β MONOMER‐ AND OLIGOMER‐SPECIFIC ANTIBODIES IN HUMAN SERUM
Author(s) -
Vukicevic Marija,
Fiorini Emma,
Knittel Delphine,
Giriens Valérie,
Chuard Nathalie,
Pfeifer Andrea,
Muhs Andreas,
Pihlgren Maria
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1277
Subject(s) - antibody , oligomer , biotinylation , monoclonal antibody , microbiology and biotechnology , chemistry , streptavidin , peptide , monomer , biochemistry , biology , biotin , immunology , organic chemistry , polymer
specific filters on pipeline-unique variants. To analyze WGS of 578 family samples and WES of 10,692 case/control samples from the Alzheimer’s Disease Sequencing Project (ADSP), structured protocols were developed and implemented for post-variant calling QC and consensus calling, and will be implemented on multiple replication sequence datasets. Conclusions: The pipeline generates fully QCed/consensus called genotypes in multiple formats, as well as extensive annotation of variants and genotypes both passing and failing the QC/ consensus calling steps. The pipeline is currently in beta-testing, and pipeline design and results of the implementation of the pipeline on both ADSP Discovery and preliminary ADSP replication datasets will be presented.