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[P2–584]: COMPARING CLINICALLY BASED VERSUS ALGORITHM‐GENERATED INTERVENTIONS IN THE CONTEXT OF ALZHEIMER's DISEASE (AD) PREVENTION
Author(s) -
Walker John Q.,
Keine Dorothy,
Caesar Emily E.,
Hristov Hollie,
Hackett Katherine,
Isaacson Richard
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1243
Subject(s) - medicine , psychological intervention , context (archaeology) , disease , personalized medicine , family medicine , bioinformatics , psychiatry , paleontology , biology
theDSE group during the intervention period.During 5 years spanning the intervention’s end and post-intervention follow-up, repeated cognitive assessments were obtained in 1,091 individuals who had been assigned to ILI or DSE. Results:Compared with DSE, assignment to ILI was associated with a mean 0.082 standard deviation (SD) relative deficit in global cognitive function (p1⁄40.010) over time. However, overweight (body mass index <30 kg/m) ILI participants had mean [95% confidence interval] 0.099 [-0.006,0.259] SD better composite cognitive function scores across follow-up while obese (body mass index >30 kg/m) ILI participants had -0.117 [-0.185, -0.049] worse mean composite cognitive function scores (interaction p1⁄40.014). For both overweight and obese participants, cognitive decline was steeper for ILI compared with DSE participants, with differences reaching nominal significance for tests of attention (p1⁄40.037) and memory (p1⁄40.031), andmarginal significance for composite cognitive function (p1⁄40.068).Conclusions:Long-term behavioral weight loss intervention was not associated with lasting cognitive benefits in adults with type 2 diabetes, and potentially small relative mean deficits among individuals who are obese.