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[P2–575]: APOE EPSILON 4 STATUS MODIFIES THE EFFECTS OF AEROBIC, RESISTANCE, OR COMBINED TRAINING ON COGNITIVE FUNCTION IN OLDER ADULTS
Author(s) -
Makino Taeko,
Umegaki Hiroyuki,
Hayashi Takahiro,
Cheng Xian Wu,
Shimada Hiroyuki,
Dodge Hiroko,
Kuzuya Masafumi
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1234
Subject(s) - repeatable battery for the assessment of neuropsychological status , cognition , apolipoprotein e , neuropsychology , medicine , repeated measures design , gerontology , cognitive training , cognitive decline , randomized controlled trial , physical therapy , aerobic exercise , analysis of variance , psychology , dementia , disease , psychiatry , statistics , mathematics
TIA. Cognitive functions weremeasured using theMontreal Cognitive Assessment (MoCA). Multiple linear regression analysis was conducted to explore the associations between leisure activity participation with WMH and the moderating effects of leisure activities upon relationship between WMH and MoCA (with respective activity x WMH volume interaction). Analyses were further stratified by low (<6 years) or high education ( 6 years). Effect of aerobic and non-aerobic physical activities was also compared. All models were adjusted with age, sex and years of education. Results:PA, but not IA, was negatively related to WMH volume (b1⁄43.45, p<.05). IA (b1⁄43.81, p<.001) contributed to the MoCA scores. Only IA, but not PA, has main effect towards MoCA score after stroke/TIA (b1⁄43.81, p<.001). Significant interaction with WMH volume was found for PA (b1⁄40.27, p<.01) but not with IA. Such interaction was found in the lower education group (b1⁄4.28, p<.01) but not in the higher education group. Conclusions: In patients with stroke or TIA, IA confers general cognitive benefits. Regular participation of PA negatively correlated with patients WMH volume and in patients with low education, cognitive benefits of PA increases with severity of WMH.