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[P2–573]: EFFECTS OF AEROBIC EXERCISE ON BRAIN METABOLISM AND GREY MATTER VOLUME IN OLDER ADULTS: RESULTS OF THE SMART TRIAL
Author(s) -
Matura Silke,
Tesky Valentina A.,
Pilatus Ulrich,
Hattingen Elke,
Fleckenstein Johannes,
Vogt Lutz,
Banzer Winfried,
Deichmann Ralf,
Lienerth Bianca,
Pantel Johannes
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1232
Subject(s) - aerobic exercise , choline , cognitive reserve , medicine , physical therapy , cognition , randomized controlled trial , vo2 max , grey matter , brain structure and function , physical medicine and rehabilitation , psychology , magnetic resonance imaging , white matter , cognitive impairment , psychiatry , blood pressure , heart rate , radiology
Background:Mild cognitive impairment (MCI) represents a transition between normal cognitive aging and dementia, and may represent a critical timeframe to promote cognitive health through behavioural strategies. Current evidence suggests physical activity (PA) and sedentary behaviour (SB) are important for cognition. However, it is unclear if PA and SB differences exist between individuals with and without MCI or if the relationships of PA and SB with cognitive function differ by MCI categorization. Thus, using cross-sectional data, we examined: 1) differences in PA and SB between individuals with and without MCI; and 2) whether associations of PA and SB with cognitive function differed by MCI categorization. Methods:We measured PA and SB in communitydwelling adults (N1⁄4150; aged 55+) using the MotionWatch8 . Using theMontreal Cognitive Assessment, we categorized individuals with MCI (<26/30) and without MCI ( 26/30). Cognitive function was indexed using the Alzheimer’s Disease Assessment Scale-Plus (ADAS-Cog Plus). We compared PA and SB based on MCI categorization, and examined relationships of ADAS-Cog Plus with PA and SB by MCI categorization. Results: Individuals with MCI (N1⁄483) had lower PA (p<0.01) and higher SB (p1⁄40.03) than individuals without MCI (N1⁄469). Higher PA and lower SB were associated with better ADAS-Cog Plus performance in the non-MCI group (b1⁄4-0.022, p1⁄40.02 and b1⁄40.012, p1⁄40.04 respectively), but not in the MCI group (b<0.001, p1⁄40.993 and b<0.001, p1⁄40.948, respectively). Conclusions: Individuals with MCI were less active and more sedentary. The relationships of these behaviours with cognitive function differed by MCI categorization; associations were only found in non-MCI individuals.