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[P2–541]: METABOLIC SYNDROME AND COGNITIVE DECLINE IN THE FRAMINGHAM HEART STUDY
Author(s) -
Gross Alden L.,
Armstrong Nicole,
Bangen Katherine,
Au Rhoda
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1199
Subject(s) - metabolic syndrome , cognitive decline , medicine , framingham heart study , abdominal obesity , national cholesterol education program , framingham risk score , hypertriglyceridemia , incidence (geometry) , effects of sleep deprivation on cognitive performance , cohort , blood pressure , risk factor , cognition , gerontology , obesity , cardiology , dementia , cholesterol , psychiatry , disease , triglyceride , physics , optics
lower total gray matter volume (b1⁄4-0.07,p<0.01). Higher HDL variability was also associated with higher total mean diffusivity (b1⁄40.12, p<0.05) and higher regional diffusivity (e.g. b frontal region1⁄40.12,p<0.05). Higher LDL variability was not associated with hippocampul, white or gray matter volumes. Higher LDL variability was borderline associated with higher total mean diffusivity (b1⁄40.08,p1⁄40.07) andwith higher regional diffusivity (e.g. b temporal region1⁄40.09,p<0.05). There were no associations with fractional anisotropy. Conclusions:Higher visit-to-visit lipid, especially HDL, variability was associated with worse markers of brain integrity in midlife. Such midlife brain changes may portend an association between lipid variability and risk of dementia.