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[P2–466]: EFFECT OF THE APOLIPOPROTEIN E E2 (APOE2) ALLELE ON MEMORY DECLINE AND INCIDENCE AND TRANSITION TO ALZHEIMER's DISEASE (AD): RESULTS FROM THE EINSTEIN AGING STUDY (EAS)
Author(s) -
Katz Mindy J.,
Wang Cuiling,
Derby Carol A.,
Lipton Richard B.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1123
Subject(s) - dementia , episodic memory , cohort , medicine , cognitive decline , psychology , incidence (geometry) , hazard ratio , gerontology , cognition , oncology , disease , psychiatry , confidence interval , physics , optics
twenty-six patients with MCI, 97 patients with AD, and 91 healthy older adults were recruited. All participants consented to examination with the MMSE-2, the MMSE, and other detailed neuropsychological assessments. Discriminant analysis of each test was used to evaluate and compare their correct classifications and sensitivity and specificity of each test was compared using receiver operating characteristic (ROC) analysis. Results: The result of discriminant validity of MMSE-2 showed that 71.1% of cases correctly identified in a discriminant analysis of patients with MCI (68.6%), patients with AD (78.4%), and healthy older adults (72.5%). The result of discriminant validity of K-MMSE showed that 67.9% of cases correctly identified in a discriminant analysis of patients with MCI (83.6%), patients with AD (68.0%), and healthy older adults (28.6%). Moreover, the AUC of the MMSE2:BV (0.708), the MMSE-2:SV (0.720), and the MMSE-2:EV (0.728) were larger than the AUC of the K-MMSE (0.703) when comparing with healthy older adults and patients with MCI. However, the AUC of the K-MMSE (0.936) was lager than the MMSE2:BV (0.930), the MMSE-2:SV (0.925), and the MMSE-2:EV (0.921) when comparing with patients with MCI and AD. Conclusions:TheMMSE-2 is more useful cognitive screening instrument for assessing cognitive impairment in a Korean population than the K-MMSE. Especially, theMMSE-2:SVand theMMSE-2:EVare more sensitive to discriminate cognitive dysfunction between healthy normal aging and patients with MCI, but when comparing between patients with MCI and AD, the MMSE-2:BV and the KMMSE are more sensitive to discriminate cognitive dysfunction.