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[P2–438]: COGNITION AND HIPPOCAMPAL PATHOLOGIC DENSITY OF α‐SYNUCLEIN, TAU AND AMYLOID‐β IN DEMENTIA WITH LEWY BODIES
Author(s) -
Ferman Tanis J.,
Aoki Naoya,
Kasanuki Koji,
Dickson Dennis W.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1094
Subject(s) - subiculum , hippocampal formation , dementia with lewy bodies , hippocampus , psychology , neuroscience , dementia , cognition , neuropathology , cognitive decline , pathology , audiology , medicine , disease , dentate gyrus
top predictors of mixed pathology. The quality-controlled rectangular data set was comprised of 39 predictors that included demographics such as age at death, sex, and education along with vascular risk factors, medical conditions, IADLs, APOE ε2 and ε4 alleles, and slopes for episodic memory, semantic memory, working memory, perceptual speed, and visuospatial ability estimated from annual follow-up visits prior to death (mean 8.9 (s.d.1⁄44.7) years). We performed a Poisson regression with robust standard errors on the top five predictors from the RF model to look at the magnitude and direction of the predictors. Results:The optimal RF model classified the two groups with 81% accuracy. The top five predictors of mixed neuropathology were greater decline in episodic and semantic memory, greater IADL impairment at final visit, slower decline in perceptual speed, and no history of thyroid disease. Rate of decline in episodic memory (p-value< 0.001) and older age at death (p-value1⁄4 0.01) were statistically significant in our Poisson regression model that included all five predictors, age at death and sex, with a one standard deviation greater decline in episodic memory associated with an 11% increase in the “risk” of mixed neuropathology. Conclusions: Investigation of longitudinal cognitive symptoms could provide a more accurate approach for ante-mortem differentiation of pure AD and other major dementia syndromes.