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[P2–431]: ALZHEIMER DISEASE (AD) AND MULTIPLE SYSTEM ATROPHY (MSA) DIAGNOSED CLINICALLY AS AD WITH GAIT ABNORMALITY
Author(s) -
Newell Kathy,
Arthur Anne
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1087
Subject(s) - atrophy , pathology , ataxia , medicine , cerebellum , ataxic gait , psychology , neuroscience
78.4% (95% CI 76.3% – 80.3%) had neuropathology indicative of AD. At last visit this increased to 81.3% (95% CI: 78.8% 83.7). Therewas no significant difference in accuracy of clinical diagnosis when data was analyzed for race, gender, education level, or time followed. Patients with ApoE genotype of ε4, ε4 were most likely to have matching clinical and neuropathological data (83.3%, p 1⁄4 0.0003) as were those with higher Geriatric Depression Scores (p1⁄4 0.012). Lewy body dementia (LBD) (29%) and frontotemporal lobar degeneration (FTLD) (19%) were the most common neuropathological diagnoses in those that were misdiagnosed as clinically having AD. Conclusions: The misdiagnosis rate of AD can be as high as 20%, even by the most experienced clinicians. With factors such as race, gender, education level, and time followed not having a significant effect, more studies are needed to examine what factors do contribute to this misdiagnosis. Reasons for the higher rate of misdiagnosis between AD and LBD also warrant further study.