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[P2–427]: DEPRESSION AND CEREBROSPINAL FLUID BIOMARKERS OF ALZHEIMER's PATHOLOGY IN MILD COGNITIVE IMPAIRMENT
Author(s) -
Stella Florindo,
Radanovic Marcia,
Loureiro Júlia Cunha,
Canineu Paulo Renato,
Pais Marcos Vasconcelos,
Valiengo Leandro L.C.,
Leme Talib Leda,
Forlenza Orestes Vicente
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1083
Subject(s) - depression (economics) , cerebrospinal fluid , medicine , dementia , cognitive impairment , pathology , gastroenterology , psychology , disease , psychiatry , economics , macroeconomics
distribution. Seventeen participants exhibited anterior dominant pattern (SVCI_A group), while 28 participants showed posterior dominant pattern (SVCI_P group). Results: The SVCI_A group showed higher frontal/global standardizes uptake value ratio (SUVR) 1.05 6 0.04 versus 0.98 6 0.04, p<0.001) while the SVCI_P group greater occipital/global (0.94 6 0.05 versus 1.05 6 0.08, p<0.001) SUVR ratio. The SVCI_A group was more likely to have APOE4 than the SVCI_P group. (70.6% versus 32.1%, p1⁄40.012) There were no significant differences of any cognitive domains between two groups. The frequencies of strictly lobar MBs or CSS tended to be higher in SVCI_P group than SVCI_A group, although there were also no statistical significances (strictly lobar CMBs: 17.9% versus 0.0%, p1⁄40.281; CSS: 14.3% versus 5.9%, p1⁄40.135). The SVCI_P group was more likely to have CAA patients (25.0% versus 5.9%, p1⁄40.132) Conclusions:Our findings suggested that SVCI with Ab (+) might be classified into anterior predominant amyloid and posterior predominant amyloid groups, which may reflect their underlying pathomechanisms.