[P2–414]: CHARACTERISING THE PROGRESSION OF ALZHEIMER's DISEASE SUBTYPES USING SUBTYPE AND STAGE INFERENCE (SUSTAIN)

ures (A)-(D) show the progression pattern of each of the four subtypes estimated by SuStaIn. The cumulative probability each region has reached a particular z-score is shown for different stages along the progression; the cumulative probability of a region going from a z-score of 0-sigma to 1-sigma ranges from 0 in white to 1 in red, the cumulative probability of a region going from a z-score of 1-sigma to 2sigma ranges from 0 in red to 1 in magenta, and the cumulative probability of a region going from a z-score of 2-sigma to 3-sigma ranges from 0 in magenta to 1 in blue, f is the proportion of subjects assigned to each subtype. CVS is the model cross-validation similarity: the average similarity of the subtype progression patterns across cross-validation folds, measured using the Bhattacharyya coefficient. The CVS ranges from 0 (no similarity) to 1 (maximum similarity). Poster Presentations: Monday, July 17, 2017 P791