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[P1–039]: IN VITRO EVALUATION OF BENZOTHIAZOLE‐BASED UREAS AS POTENTIAL ABAD/17β‐HSD10 MODULATORS FOR ALZHEIMER'S DISEASE THERAPEUTICS
Author(s) -
Aitken Laura,
Hroch Lukas,
Hughes Rebecca,
Udo Thijs S.,
Benek Ondrej,
Guest Patrick N.,
Musilek Kamil,
Smith Terry K.,
GunnMoore Frank J.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.106
Subject(s) - benzothiazole , cytotoxicity , chemistry , bioisostere , potency , pharmacology , in vitro , biochemistry , small molecule , enzyme , biology , chemical synthesis
production of multisyllabic words (PPA-NF) and naming deficits or working memory (PPA-L and PPA-NC), based on principles of errorless learning. Thirty-minute rehabilitation sessions were offered twice a week, with daily workouts at home. The trained items (pre and post-treatment) and untrained items (pre and post-treatment) were compared. Generalization to other language tasks and functional communication was also informed. Followup results are reported for three patients. Results: The sample comprised 5 women and 8 men. Mean age was 65 years and mean schooling was 13.7 years. A significant improvement for treated items was seen for all patients. Nine patients also improved in untreated items. In addition, seven generalized for other tasks. Three patients were evaluated one month after the end of the treatment and demonstrated maintenance of treatment results. Conclusions:Even being a progressive syndrome, patients were able to relearn target vocabulary and strategies to improve sentence construction during the active phase of treatment. These preliminary results suggest that linguistic-based treatment strategies may constitute an effective approach in the clinical management of PPA patients.