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[P2–399]: CORRELATION OF GREY MATTER NETWORK MEASURES IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS
Author(s) -
Kate Mara ten,
Tijms Betty M.,
Konijnenberg Elles,
Braber Anouk,
Boomsma Dorret I.,
Scheltens Philip,
Barkhof Frederik,
Visser Pieter Jelle
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1054
Subject(s) - grey matter , monozygotic twin , betweenness centrality , correlation , twin study , psychology , similarity (geometry) , white matter , mathematics , statistics , centrality , magnetic resonance imaging , biology , artificial intelligence , medicine , genetics , heritability , computer science , geometry , radiology , image (mathematics)
pattern with 4 different quadrants shown for 3 s (sample). After a brief delay (simultaneous condition, 0 s, 4 s, and 12 s) four similar patterns appeared for the subject tomatchwith the sample (Fig.1). Five trials of each DMS condition were administered interspersed with visual fixation baseline. Six right-handed adults performed DMS during fMRI at 3T. The Pronto Toolkit was used to optimize preprocessing pipelines (Churchill PloSone-2015); Z-scored maps of each trial vs. baseline were obtained using a Gauss Na€ıve Base (GNB) model. Principal Component Analysis (PCA) was performed on the 6 Z-scored maps to obtain brain patterns that explained the most variance across subjects.Results:Fig. 2 depicts group brain maps for the 4 s and 12 s delay conditions. Increased brain activity is observed in medial temporal lobe (MTL) structures during performance with 12 s delay compared to 4 s delay, including recruitment of left hippocampus, as well as increased activity in superior, middle, and inferior frontal gyri and the anterior cingulate. The differences in brain activity patterns are consistent with increased memory demands with increasing time delay. Activity is also observed inmotor, premotor, and ventral premotor cortex consistent with fine motor control of the hand. Conclusions: Results suggest that the tablet with VFHP provides brain activity consistent with performing ecologically valid computerized DMS. This intuitive setup and analysis helps to accurately map activity in the MTL associated with different memory demands.