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[P2–393]: GRADIENT ECHO PLURAL CONTRAST MRI PROVIDES NEW SURROGATE MARKERS OF BRAIN PATHOLOGY IN ALZHEIMER's DISEASE
Author(s) -
Yablonskiy Dmitriy A.,
Zhao Yue,
Cairns Nigel J.,
Hassenstab Jason,
Benzinger Tammie L.S.,
Astafiev Serguei V.,
Wen Jie,
Raichle Marcus E.,
Morris John C.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1048
Subject(s) - surrogate endpoint , pathology , precuneus , amyloid (mycology) , dementia , alzheimer's disease , neuroscience , medicine , disease , psychology , cognition
AD dementia (CDR 1) who underwent MRI 11 months prior to expiration. (A) MPRAGE image, (B) GEPCI R2t* map. GEPCI R2t* in the hippocampus (outlined in yellow, segmented based on FreeSurfer) shows hypointense lesions (reduced R2t* values) consistent with the loss of cellular integrity even in the remaining part of hippocampus, thus suggesting higher sensitivity of GEPCI R2t* measurements to tissue neuronal loss as compared to standard volumetric measurements. This is confirmed by direct neuropathological examination shown in panel C (hippocampal area), obtained from the postmortem studies from this participant. Severe neuronal loss (hematoxylin and eosin stain) is indicated by the only present neuron on this image (indicated by the arrow). Also shown (panel D) is an example from hippocampus of a 79-year-old female with Alzheimer disease showing preservation of many neurons. Scale bars are 0.1 mm.