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[P2–388]: INTRINSIC CONNECTIVITY NETWORKS IN POSTERIOR CORTICAL ATROPHY: A ROLE FOR THE PULVINAR?
Author(s) -
Fredericks Carolyn A.,
Brown Jesse,
Deng Jersey,
Ossenkoppele Rik,
Rankin Katherine,
Kramer Joel H.,
Miller Bruce L.,
Rabinovici Gil D.,
Seeley William W.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1043
Subject(s) - default mode network , posterior cortical atrophy , neuroscience , atrophy , psychology , neuropsychology , voxel based morphometry , salience (neuroscience) , functional connectivity , medicine , magnetic resonance imaging , cognition , disease , pathology , white matter , dementia , radiology
segregation, respectively. Metrics that showed significant differences were then used for the individual patient contribution analysis. This latter analysis was performed by extracting the patient contribution to a metric for the network constructed using healthy controls plus the patient. The Rey Complex Figure test was used for episodic memory assessment. Results:The global network modularity was increased while global efficiency decreased in the MCI network compared with the control network.Most important, only the individual patient contribution to the global network modularity showed a significant negative correlation with episodic memory as shown in the figure. Conclusions: Episodic memory in MCI inversely correlates with the patient contribution to CBF network modularity, which warrants further research to develop a CBF connectivity-based biomarker at the individual level as episodic memory decline is the hallmark and major symptom in patients that progress to AD dementia.