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[P1–037]: SHORT‐TERM REHABILITATION FOR LINGUISTIC IMPAIRMENTS IN PRIMARY PROGRESSIVE APHASIA: A CASE SERIES
Author(s) -
Machado Thaís Helena,
Campanha Aline Carvalho,
Baradel Roberta Roque,
CartheryGoulart Maria Teresa,
Caramelli Paulo
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.104
Subject(s) - primary progressive aphasia , aphasia , rehabilitation , sentence , psychology , working memory , audiology , physical therapy , medicine , cognitive psychology , psychiatry , natural language processing , computer science , cognition , disease , dementia , frontotemporal dementia
(2.3) mL/kg/min, p< 0.001). Brain metabolic analysis revealed a bilateral reduction of rBGM in both anterior temporal poles, left frontal gyrus, left anterior cingulate cortex, right hippocampus, left medial frontal gyrus and bilateral caudate nuclei. In contrast, there was an increase in rBGM in the right precuneus and left inferior frontal gyrus (Figure1). Factorial models were used to create latent variables reflecting the salience network (SN) and default mode network (DMN) based on regions with rBGM changes found after the AT. A confirmatory factor model was used to test the hypothesis that ATwould induce rBGM changes (decrease) in regions of the SN. This decrement may reflect improved control of other networks and ultimately, would induce an increment in rBGM in the precuneus, an important node of the DMN. Regions of the temporal pole were in between these regions and are highly connected with both networks. Values of model fit reached statistical significance (figure2), demonstrating that this model explain the variance of the measured data. Conclusions: AT improved aerobic fitness, cognition and changed rBGM in nodes od the DMN and SN in subjects with MCI.