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[P2–378]: NEUROPSYCHOLOGICAL AND NEUROANATOMICAL CORRELATES OF EVENT‐RELATED POTENTIALS IN PATIENTS WITH ALZHEIMER's DISEASE
Author(s) -
McGeown William J.,
Cecchi Marco,
Fadem K.C.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1033
Subject(s) - p3a , n100 , audiology , psychology , event related potential , p3b , planum temporale , neuroscience , mismatch negativity , neuropsychology , cognition , electroencephalography , medicine
Background:Discrimination of patients with Alzheimer’s disease (AD) from age-matched healthy adults has been demonstrated using event-related potentials (ERP). In this study we investigated the associations between ERP measures from an oddball paradigm and regional gray matter (GM). A second study objective was to identify ERP measures that could reflect disease staging (in concordance with neuropsychological assessment and hippocampal atrophy). Methods: Sixty-two patients with mild AD (MMSE 21-26) were evaluated using a comprehensive neuropsychological assessment battery, an active auditory oddball ERP paradigm, and structural MRI. Voxel-based morphometry and cortical thickness (CT) assessment were used to quantify GM across multiple regions of interest. Correlation analyses assessed the relationship between the ERP measures (e.g., component amplitude and latency) and regions of interest. Results: Accuracy in the oddball task was associated with CT within the anterior cingulate bilaterally and the left insula. Measures such as the Distractor and Standard N100 amplitudes (associated with detection of acoustic change) correlated positively with CT in the right supramarginal gyrus. Distractor P3a amplitude (linked with directing attention to novel stimuli) was positively correlated with CTwithin regions such as the anterior cingulate, the transverse temporal and superior temporal gyri. Target P3b amplitude (linked to attention/working memory) correlated with CTwithin regions such as the transverse and middle temporal gyri. In relation to disease staging, measures such as Distractor P3a amplitude were correlated with performance on the Alzheimer Disease Assessment Scale – cognitive subscale (ADAS-cog), whereas ERP components such as Distractor N100 latency, Standard P200 latency, Target P200 amplitude, and Slow Wave Target latency correlated with hippocampal volume. Conclusions:This study shows associations between a range of ERP components and GM in various brain regions in patients with mild AD. Knowledge of these associations offers greater insight into the neurophysiology behind the oddball ERP test and its applications in the detection of AD. In addition, we report correlations of ERP measures with hippocampal volume and neuropsychological tests. Given the simplicity of the ERP test and the demonstrated links to established measures for disease staging some of the ERP measures might be useful for patient monitoring.