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[P2–371]: CEREBRAL MICROBLEEDS ARE ASSOCIATED WITH TEMPORAL LOBE HYPOMETABOLISM IN ALZHEIMER's DISEASE
Author(s) -
SheikhBahaei Nasim,
Sajjadi S. Ahmad,
Manavaki Roido,
O'Brien John T.,
Gillard Jonathan H.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1026
Subject(s) - medicine , standardized uptake value , temporal lobe , positron emission tomography , concordance , cardiology , pathology , nuclear medicine , epilepsy , psychiatry
performance. Amyloid load in the AT network correlated with worse BNT (r1⁄4-0.13, p1⁄40.001) performance, but even more so with worse DR (r1⁄4-0.22, p<0.001). Moreover, after controlling for global cortical amyloid burden, none of the regional associations remained significant. By contrast, globally controlled glucose hypometabolism correlated with cognitive dysfunction in a network-specific manner, correlating with DR in the PM (p<0.001) and with BNT in the AT (p<0.001), but not vice versa (both p>0.05). Conclusions: In contrast to FDG-PET measured hypometabolism, network-specific amyloid load does not specifically associate with dysfunction in the respective cognitive domain, corroborating recent evidence of negligible local neurotoxicity of accumulated amyloid-b protein.