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[P2–365]: PREDICTION OF FUNCTIONAL DISABILITY IN VASCULAR DEPRESSION
Author(s) -
Lee Kang Soo,
Chang Ki Jung,
Hong Chang Hyung,
Choi Tai Kiu,
Son Sang Joon
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1020
Subject(s) - depression (economics) , psychology , gee , executive dysfunction , hyperintensity , stroop effect , medicine , physical therapy , cardiology , psychiatry , cognition , generalized estimating equation , magnetic resonance imaging , economics , statistics , mathematics , radiology , neuropsychology , macroeconomics
matter density (GMD) from VBM, processed using standard techniques. Age, sex, and education were used as covariates for all analyses, as well as APOE ε4 status and total intracranial volume for the [F]Florbetapir and MRI analyses, respectively. Significant findings for [F]Flortaucipir and [F]Florbetapir were shown at p<0.01 (uncorrected) and at a minimum cluster threshold (k) of 50 voxels, while MRI results were displayed at p<0.001 (uncorrected) and k1⁄450 voxels. Results:Higher % errors during the one card learning test was associated with higher levels of both amyloid and tau deposition and reduced GMD. Notably, higher % errors was associated amyloid in the temporal and parietal cortices (Figure 1A). High tau load was also associated with a higher % errors, predominantly in the parietal cortex (Figure 1B). Atrophy showed association with % errors in only focal regions (Figure 1C). Conclusions: Errors in visual learning were more associated with amyloid deposition than tau load or atrophy. These findings suggest amyloid pathology may play an important role in visual memory in cognitively healthy older adults and that this test may be a good predictor of increased AD risk and future cognitive decline. Future studies in larger samples are warranted.