Premium
[P2–362]: DIFFERENTIAL EFFECT OF GLUCOSE METABOLISM AND INTRINSIC FUNCTIONAL CONNECTIVITY ON MEMORY PERFORMANCE OVER THE SPECTRUM OF ALZHEIMER'S DISEASE
Author(s) -
Dronse Julian,
Dillen Kim N.H.,
Jacobs Heidi I.L.,
Reutern Boris,
Richter Nils,
Onur Oezguer A.,
Stoffels Gabriele,
Kops Elena Rota,
Tellmann Lutz,
Shah N. Jon,
Langen KarlJosef,
Fink Gereon R.,
Kukolja Juraj
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1017
Subject(s) - resting state fmri , default mode network , neuroscience , voxel , dementia , alzheimer's disease , cognition , psychology , disease , medicine , radiology
left hippocampus than AD patients. In the tau PET study, AD patients exhibited greater SUVR in the bilateral amygdala, the left hippocampus and the left putamen relative to CN subjects. Except for the left putamen, MCI patients had greater SUVR in the same regions relative to CN subjects. Contrary to the amyloid PET study, AD patients had greater SUVR in the left hippocampus than MCI patients. Conclusions: In this study, we found that SUVR of patients withADspectrum significantly increases comparedwithCNsubjects in the several subcortical surface.Because result of group comparison betweenCNandADwas similar to result of comparison betweenCN and MCI, the use of PET enables the early detection of pathophysiological changes in patients with AD. Also, amyloid PETand tau PET findings is shown specific retention in the sub-cortical surface.