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[P2–346]: EXCESSIVE NEOCORTICAL TAU ACCUMULATION IN DOWN SYNDROME
Author(s) -
Yoon So Hoon,
Cho Hanna,
Choi Jae Yong,
Lee Seung Ha,
Baek Min Seok,
Ryu Young Hoon,
Lee Myung Sik,
Lyoo Chul Hyoung
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1000
Subject(s) - neocortex , trisomy , proband , down syndrome , standardized uptake value , chromosome 21 , medicine , positron emission tomography , cortex (anatomy) , cerebral cortex , neuroscience , cardiology , pathology , psychology , endocrinology , nuclear medicine , chromosome , biology , psychiatry , genetics , gene , mutation
areas included the bilateral insula, inferior temporal lobes, cingulate cortex and hippocampus. Conclusions: In asymptomatic people, APOE-ε4 moderates the association between regional GM volume and cognitive performance in episodic memory. These data shed light on the impact of such risk allele on cognitive resources in the healthy population and further improve our knowledge on the mechanisms relating APOE, cognitive decline and patterns of brain atrophy.