[P2–346]: EXCESSIVE NEOCORTICAL TAU ACCUMULATION IN DOWN SYNDROME

areas included the bilateral insula, inferior temporal lobes, cingulate cortex and hippocampus. Conclusions: In asymptomatic people, APOE-ε4 moderates the association between regional GM volume and cognitive performance in episodic memory. These data shed light on the impact of such risk allele on cognitive resources in the healthy population and further improve our knowledge on the mechanisms relating APOE, cognitive decline and patterns of brain atrophy.