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[P1–026]: THE RELATIONSHIP BETWEEN CEREBRAL GLUCOSE METABOLISM AND COGNITION IN ADVANCE
Author(s) -
Forrester Sarah N.,
Leoutsakos JeannieMarie S.,
Lozano Andres M.,
Fosdick Lisa,
Targum Steven,
Lyketsos Constantine,
Smith Gwenn S.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.093
Subject(s) - carbohydrate metabolism , fornix , medicine , cognitive decline , endocrinology , psychology , hippocampus , neuroscience , dementia , disease
structure byTCC revealed that the APOEgene cluster conformationally interactedwith some genes involved in AD pathology. The chromatin interactions of the APOE gene cluster were observed in the neuroblastoma and astrocytoma cell lines. Conclusions: Our study suggested that some AD-associated variants exert a deleterious effect on the transcriptional regulation of genes at distinct genomic regions through chromatin higher-order structure.