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[P1–008]: RELATIONSHIP BETWEEN TAU POSITRON EMISSION TOMOGRAPHY WITH [18F]‐AV‐1451 AND LONGITUDINAL CORTICAL ATROPHY IN ALZHEIMER DISEASE
Author(s) -
Mishra Shruti,
Gordon Brian A.,
Blazey Tyler,
Su Yi,
Christensen Jon,
Jackson Kelley,
Hornbeck Russ C.,
Morris John C.,
Ances Beau M.,
Benzinger Tammie L.S.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.075
Subject(s) - entorhinal cortex , atrophy , positron emission tomography , nuclear medicine , standardized uptake value , magnetic resonance imaging , alzheimer's disease , neuroimaging , medicine , temporal cortex , primary progressive aphasia , psychology , dementia , neuroscience , pathology , hippocampus , radiology , disease , frontotemporal dementia
temporal gyrus and temporal pole, only among CN and EMCI participants (see Figure). Among CN and EMCI participants, those with the combination of E4+ and Amy+ status had no differences in CoTh, but were more cognitively impaired than those who were both E4and Amyas well as those who were E4and Amy+ and E4+ and Amy-. Conclusions: Higher amyloid load is associated with decreased CoTh in all diagnostic groups, independent of E4 status. E4+ status is not associated with any additional decrease in CoTh. But among CN and EMCI participants only, E4+ status is associated with increased CoTh in most brain regions, especially in limbic regions, and independent of Amy+ status. E4+ status and Amy+ status is each associated with cognitive impairment.