Premium
[P1–008]: RELATIONSHIP BETWEEN TAU POSITRON EMISSION TOMOGRAPHY WITH [18F]‐AV‐1451 AND LONGITUDINAL CORTICAL ATROPHY IN ALZHEIMER DISEASE
Author(s) -
Mishra Shruti,
Gordon Brian A.,
Blazey Tyler,
Su Yi,
Christensen Jon,
Jackson Kelley,
Hornbeck Russ C.,
Morris John C.,
Ances Beau M.,
Benzinger Tammie L.S.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.075
Subject(s) - entorhinal cortex , atrophy , positron emission tomography , nuclear medicine , standardized uptake value , magnetic resonance imaging , alzheimer's disease , neuroimaging , medicine , temporal cortex , primary progressive aphasia , psychology , dementia , neuroscience , pathology , hippocampus , radiology , disease , frontotemporal dementia
temporal gyrus and temporal pole, only among CN and EMCI participants (see Figure). Among CN and EMCI participants, those with the combination of E4+ and Amy+ status had no differences in CoTh, but were more cognitively impaired than those who were both E4and Amyas well as those who were E4and Amy+ and E4+ and Amy-. Conclusions: Higher amyloid load is associated with decreased CoTh in all diagnostic groups, independent of E4 status. E4+ status is not associated with any additional decrease in CoTh. But among CN and EMCI participants only, E4+ status is associated with increased CoTh in most brain regions, especially in limbic regions, and independent of Amy+ status. E4+ status and Amy+ status is each associated with cognitive impairment.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom