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[P1–206]: APOE4 PROMOTES THE DYSFUNCTION OF BRAIN BLOOD VESSELS, GLIAL NEUROINFLAMMATION, AND ACCUMULATION OF SENILE PLAQUES IN THE PREFRONTAL CORTEX OF APPSWE/PS1DE9 ALZHEIMER's DISEASE MODEL MICE
Author(s) -
Kaneko Jun,
Hisatsune Tatsuhiro,
Tochigi Mami
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.026
Subject(s) - senile plaques , neuroinflammation , microglia , pathology , cortex (anatomy) , genetically modified mouse , pericyte , apolipoprotein e , immunostaining , hippocampus , prefrontal cortex , biology , alzheimer's disease , neuroscience , medicine , transgene , immunohistochemistry , immunology , disease , gene , inflammation , endothelial stem cell , biochemistry , cognition , in vitro