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Post‐traumatic stress disorder and risk of dementia among members of a health care delivery system
Author(s) -
Flatt Jason D.,
Gilsanz Paola,
Quesenberry Charles P.,
Albers Kathleen B.,
Whitmer Rachel A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.04.014
Subject(s) - dementia , hazard ratio , medicine , depression (economics) , confidence interval , psychiatry , risk factor , incidence (geometry) , proportional hazards model , demographics , medical record , comorbidity , demography , disease , physics , sociology , optics , economics , macroeconomics
Post‐traumatic stress disorder (PTSD) is associated with an increased risk of dementia in male veterans, but little is known in females and civilians. Methods PTSD and comorbidities were abstracted from medical records from 1/1/1996 to 12/31/2001. Dementia incidence from 1/1/2002 to 12/31/2014 in 499,844 health care members aged 60+ years over an average of 8.2 years. Cox proportional hazard models were adjusted for age, demographics, and comorbidities. Results PTSD was associated with increased risk of dementia over an average of 8 years of follow‐up (females: hazard ratio [HR] = 1.59, 95% confidence interval [CI] = 1.30–1.95; males: HR = 1.96, 95% CI = 1.51–2.55). There was a two‐fold risk of dementia in those with both PTSD and depression (females: HR = 2.08; 95% CI = 1.66–2.59; males: HR = 2.06; 95% CI = 1.47–2.91) versus those without. Discussion PTSD was a risk factor for dementia in both sexes, with a heightened risk in those with comorbid depression.