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Brain function and structure and risk for incident diabetes: The Atherosclerosis Risk in Communities Study
Author(s) -
Bancks Michael P.,
Alonso Alvaro,
Gottesman Rebecca F.,
Mosley Thomas H.,
Selvin Elizabeth,
Pankow James S.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.04.006
Subject(s) - diabetes mellitus , medicine , cohort , hazard ratio , cohort study , prospective cohort study , confidence interval , magnetic resonance imaging , brain structure and function , cognition , psychiatry , endocrinology , radiology
Diabetes is prospectively associated with cognitive decline. Whether lower cognitive function and worse brain structure are prospectively associated with incident diabetes is unclear. Methods We analyzed data for 10,133 individuals with cognitive function testing (1990–1992) and 1212 individuals with brain magnetic resonance imaging (1993–1994) from the Atherosclerosis Risk in Communities cohort. We estimated hazard ratios for incident diabetes through 2014 after adjustment for traditional diabetes risk factors and cohort attrition. Results Higher level of baseline cognitive function was associated with lower risk for diabetes (per 1 standard deviation, hazard ratio = 0.94; 95% confidence interval = 0.90, 0.98). This association did not persist after accounting for baseline glucose level, case ascertainment methods, and cohort attrition. No association was observed between any brain magnetic resonance imaging measure and incident diabetes. Discussion This is one of the first studies to prospectively evaluate the association between both cognitive function and brain structure and the incidence of diabetes.