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Family history and TOMM40 '523 interactive associations with memory in middle‐aged and Alzheimer's disease cohorts
Author(s) -
Willette Auriel A.,
Webb Joseph L.,
Lutz Michael W.,
Bendlin Barbara B.,
Wennberg Alexandra M.,
Oh Jennifer M.,
Roses Allen,
Koscik Rebecca L.,
Hermann Bruce P.,
Dowling N. Maritza,
Asthana Sanjay,
Johnson Sterling C.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.03.009
Subject(s) - biomarker , cognitive decline , alzheimer's disease , disease , cognition , family history , episodic memory , medicine , biology , oncology , gerontology , genetics , neuroscience , dementia
Family history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa ( TOMM40 ) rs10524523 ('523) poly‐T length on memory decline. Methods For 912 nonapolipoprotein ε4 middle‐aged adults and 365 aged adults across the AD spectrum, linear mixed models gauged FH and TOMM40 '523 interactions on memory and global cognition between baseline and up to 10 years later. A cerebrospinal fluid mitochondrial function biomarker was also assessed. Results For FH negative participants, gene‐dose preservation of memory and global cognition was seen for “very long” versus “short” carriers. For FH positive, an opposite gene‐dose decline was seen for very long versus short carriers. Maternal FH was a stronger predictor in aged, but not middle‐aged, participants. Similar gene‐dose effects were seen for the mitochondrial biomarker aspartate aminotransferase. Discussion These results may clarify conflicting findings on TOMM40 poly‐T length and AD‐related decline.