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Sleep changes without medial temporal lobe or brain cortical changes in community‐dwelling individuals with subjective cognitive decline
Author(s) -
Lauriola Mariella,
Esposito Roberto,
Delli Pizzi Stefano,
Zambotti Massimiliano,
Londrillo Francesco,
Kramer Joel H.,
Rabinovici Gil D.,
Tartaro Armando
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.11.006
Subject(s) - sleep (system call) , cognitive decline , actigraphy , cognition , psychology , audiology , temporal lobe , magnetic resonance imaging , effects of sleep deprivation on cognitive performance , wakefulness , medicine , neuroscience , dementia , disease , electroencephalography , circadian rhythm , computer science , epilepsy , radiology , operating system
Subjective cognitive decline (SCD) is a risk factor for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Although sleep has been shown to be altered in MCI and AD, little is known about sleep in SCD. Methods Seventy cognitively normal community‐dwelling participants were classified as SCD (32) or controls (38) using the Subjective Cognitive Decline Questionnaire. Sleep was assessed using actigraphy and diaries. FreeSurfer was used for performing medial temporal lobes (MTLs) and brain cortical parcellation of 3T magnetic resonance images. Multiple regression models were used to assess the presence of sleep, MTL, or regional cortical differences between groups. Results Objective sleep was disrupted in SCD participants, which showed increased nighttime wakefulness and reduced sleep efficiency. No group differences emerged in subjective sleep or magnetic resonance imaging outcomes. Discussion Objective sleep resulted disrupted in community‐dwelling SCD, without any subjective sleep or cortical change. Sleep assessment/intervention in SCD might help prevent/delay AD onset.