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Defining imaging biomarker cut points for brain aging and Alzheimer's disease
Author(s) -
Jack Clifford R.,
Wiste Heather J.,
Weigand Stephen D.,
Therneau Terry M.,
Lowe Val J.,
Knopman David S.,
Gunter Jeffrey L.,
Senjem Matthew L.,
Jones David T.,
Kantarci Kejal,
Machulda Mary M.,
Mielke Michelle M.,
Roberts Rosebud O.,
Vemuri Prashanthi,
Reyes Denise A.,
Petersen Ronald C.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.08.005
Subject(s) - positron emission tomography , cut point , nuclear medicine , standardized uptake value , deoxyglucose , medicine , biomarker , pet imaging , amyloid (mycology) , alzheimer's disease , diagnostic accuracy , cut off , psychology , disease , pathology , chemistry , mathematics , statistics , physics , biochemistry , power (physics) , quantum mechanics
Our goal was to develop cut points for amyloid positron emission tomography (PET), tau PET, flouro‐deoxyglucose (FDG) PET, and MRI cortical thickness. Methods We examined five methods for determining cut points. Results The reliable worsening method produced a cut point only for amyloid PET. The specificity, sensitivity, and accuracy of cognitively impaired versus young clinically normal (CN) methods labeled the most people abnormal and all gave similar cut points for tau PET, FDG PET, and cortical thickness. Cut points defined using the accuracy of cognitively impaired versus age‐matched CN method labeled fewer people abnormal. Discussion In the future, we will use a single cut point for amyloid PET (standardized uptake value ratio, 1.42; centiloid, 19) based on the reliable worsening cut point method. We will base lenient cut points for tau PET, FDG PET, and cortical thickness on the accuracy of cognitively impaired versus young CN method and base conservative cut points on the accuracy of cognitively impaired versus age‐matched CN method.