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P4‐403: Therapeutic Treatment with an All‐D‐Enantiomeric Peptide Improves Cognitive Impairment in Old Appswe/Ps1 Transgenic Mice
Author(s) -
Schemmert Sarah,
Schartmann Anna Elena,
Kutzsche Janine,
Willuweit Antje,
Willbold Dieter
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.07.148
Subject(s) - morris water navigation task , genetically modified mouse , therapeutic effect , in vivo , placebo , transgene , medicine , open field , pharmacology , endocrinology , chemistry , pathology , biochemistry , biology , gene , alternative medicine , microbiology and biotechnology , hippocampal formation
pathologic aging conditions such as dementia (e.g., Belleville, Chertkow, & Gauthier, 2007). Existing literature shows that attention can be improved with training (e.g., Sohlberg &Mateer, 2001). Backgroundmusic is an accessible and typically enjoyable tool that may exogenously facilitate attention and counteract some of the attentional declines in older adults who are healthy or in pre-clinical stages of Alzheimer’s Disease. Two particular properties of a musical piece (1) mode (i.e., major, minor, or atonal), and (2) tempo (i.e., stimulative or sedative) influence affect, arousal, and cognitive function; These properties may interact with older adults’ prioritized affective goals, ultimately enhancing or hindering cognitive performance on attention-demanding tasks (e.g., Husain, Thompson, & Schellenberg, 2002; Mather & Carstensen, 2005; Thayer, Hansen, Saus-Rose, & Johnson, 2009). Methods: Six musical pieces were selected to represent different combinations of mode and tempo. Older adults (i.e., 65 80 years-old; n 1⁄4 22) complete theMulti-Source Interference Task assessing selective attention (MSIT; Bush & Shin, 2006) at baseline and under the six counterbalanced musical conditions. In each condition, participants self-report their motivation and effort, as well as their affect and arousal on the Activation-Deactivation Adjective Checklist (Thayer, 1986).Results:MSIT performance (i.e., accuracy and reaction times) is analyzed in a repeated-measures ANCOVA, with MSIT performance and self-reported motivation and effort at baseline as covariates. Mediated regression analyses assess whether MSIT performance is mediated by arousal and/or affect. Conclusions: Results indicate which specific type of musical piece may counteract older adults’ declines in selective attention. Implications are discussed and are relevant to personal and community selections of background music to facilitate older adults’ performance on daily attention-demanding tasks.