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P4‐354: Subjective Cognitive Concerns are Associated with Objective Memory Performance in Older Caucasian but not African‐American Persons
Author(s) -
Jackson Jonathan D.,
Rentz Dorene M.,
Aghjayan Sarah L.,
Buckley Rachel F.,
Meneide Tamy-Fee,
Sperling Reisa A.,
Amariglio Rebecca
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.07.099
Subject(s) - african american , race (biology) , socioeconomic status , association (psychology) , episodic memory , cognition , psychology , dementia , effects of sleep deprivation on cognitive performance , multilevel model , medicine , clinical psychology , demography , gerontology , disease , psychiatry , population , history , ethnology , botany , environmental health , machine learning , sociology , computer science , psychotherapist , biology
logical battery, participants completed the California Verbal Learning Test (CVLT-II), Brief Visuospatial Memory Test-Revised (BVMT-R), and Benton Facial Recognition Test (BFRT). A mixed ANOVAwas used to analyze behavioural responses as a function of valence and group. Results:No group differences on the BFRTwere found. On the VALENCE task, sd-aMCI rated faces more positively compared to DEP (p1⁄4.019). Further, neutral faces were rated more positively by sd-aMCI relative to CN and DEP (F[2, 64]1⁄47.3, p1⁄4.001). On the LABEL task, a group x valence interaction revealed that sd-aMCI were more accurate in labelling neutral faces compared to DEP (F[2, 63]1⁄45.4, p1⁄4.007), who incorrectly misattributed neutral as sad. In sd-aMCI, better delayed recall on BVMT-R was associated with decreased accuracy in labelling fearful expressions, and more positive ratings of happy faces (Spearman’s rho1⁄4-.55, p1⁄4.026; rho1⁄4-.51, p1⁄4.04 respectively), with a similar inverse association between the latter and CVLT-II delayed recall (rho1⁄4-.59, p1⁄4.017). Conclusions: Intact perception of facial features and recognition of emotional expressions, together with more positive valence judgements of neutral faces, suggest that sd-aMCI is associated with a positive bias in interpretation of facial expressions. The inverse associations betweenmemory and the positivity bias support the hypothesis that preclinical Alzheimer’s disease is characterized by a positive bias in early processing of emotional information, which may attenuate with disease progression.