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P4‐327: Body Mass Index (BMI) Effects on Regional Brain Volumes in Mild Cognitive Impairment (MCI)
Author(s) -
Sanderlin Ashley H.,
Todem David,
Bozoki Andrea C.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.07.071
Subject(s) - brain size , body mass index , overweight , neuroimaging , dementia , psychology , medicine , cingulum (brain) , cardiology , neuroscience , magnetic resonance imaging , white matter , radiology , fractional anisotropy , disease
(aka AV1451) and PiB PET imaging within 6 months of responding to three SCC questionnaires. An SCC composite was created using z-transformed memory subscales from the Memory Functioning Questionnaire, the Everyday Cognition Scale, and the adapted Structured Telephone Inventory for Dementia Assessment. Results: Greater EC tau was associated with greater SCC (b1⁄40.39, p<.001) after taking into account age, depressive symptoms, sex and education. IT tau was marginally associated (b1⁄40.18, p1⁄4.16). After interactions between tau and Ab were included, no interactive effect of EC tau and Ab was found on SCC (p1⁄4.93), but an IT and Ab interaction was now marginally associated with greater SCC (p1⁄4.07). Conclusions: This is the first study to demonstrate regionally-specific patterns of association between tau burden and SCC. Specifically, EC tau was strongly associated with greater SCC, but the effect was independent of Ab burden. Increasing IT tau deposition, on the other hand, was related to greater SCC only within the context of increasing Ab burden. As such, both tau and Ab are associated with SCC and appear to becomemultiplicative under certain circumstances. It is possible that IT tau-driven SCC reflects individuals likely on the AD trajectory, whereas EC-related SCC captures a range of phenomena including normal aging, in which EC tauopathy is very common. It remains to be seen whether regional tau underlies qualitatively different SCC phenotypes.