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P4‐296: Cerebral Amyloid‐β and Gait Speed in Older Adults Without Dementia: Influence of Cognition and APOE‐E4 Genotype
Author(s) -
Nadkarni Neelesh K.,
Perera Subashan,
Snitz Beth E.,
Price Julie,
Mathis Chester,
Klunk William E.,
Williamson Jeff,
DeKosky Steven,
Lopez Oscar L.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.07.039
Subject(s) - dementia , gait , medicine , pittsburgh compound b , cognition , stroke (engine) , apolipoprotein e , effects of sleep deprivation on cognitive performance , cognitive decline , physical therapy , physical medicine and rehabilitation , cardiology , psychology , disease , psychiatry , mechanical engineering , engineering
that subjects with ‘523-S/S had faster decline in global cognition than subjects with ‘523-S/VL (p1⁄4.002) or ‘523-VL/VL (p1⁄4.030). The same association was observed in episodic memory (p1⁄4.0004 for ‘523-S/VL and p1⁄4.010 for ‘523-VL/VL) and semantic memory (p1⁄4.002 for ‘523-S/VL and p1⁄4.050 for ‘523-VL/VL), but not significant (all ps>.05) in working memory, processing speed or visuospatial ability. Conclusions:Our data reveal an association of the APOE ε3/3-TOMM40 ‘523 haplotypes with cognitive decline in community based older persons, such that the VL poly-Tat the TOMM40 ‘523 locus is related to less decline, primarily in episodic and semantic memory.