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P4‐283: Tracking Regional Connectivity Dynamics in Patients with Mild Cognitive Impairment And Alzheimer’s Disease
Author(s) -
Sun Yu,
Zhu Zhaojun,
Niu Haijing,
Han Ying
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.07.025
Subject(s) - dynamic functional connectivity , default mode network , resting state fmri , neuroscience , disconnection , functional connectivity , cognitive impairment , cognition , correlation , psychology , mathematics , geometry , political science , law
during sample collection shows that non-specific binding through the storage collection tube is significantly reduced. It also shows that adding Tween20 after sample storage of containers without Tween20, most of the Ab species lost to non-specific binding is recovered. Conclusions:The direct dripping method is recommended to collect CSF with immediate addition of 10%Tween20. For serial sample collections using a pump with tubing, we recommend to flush the tubing before CSF sampling to mitigate non-specific binding of Ab species to the tubing. The addition of 10% Tween20 immediately into collection container is recommended to minimize non-specific binding of Ab species to the container. We recommend not transferring the CSF samples to secondary storage container if 10%Tween 20 has not been added prior to transfer.