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P4‐280: Head‐to‐Head Comparison of Image Analysis Methods in Longitudinal Alzheimer’s Disease FDG PET Studies
Author(s) -
Klein Gregory,
Sampat Mehul,
Staewen Davis,
Suhy Joyce,
Reiman Eric M.,
Chen Kewei
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.07.022
Subject(s) - neuroimaging , region of interest , precuneus , voxel , nuclear medicine , alzheimer's disease neuroimaging initiative , posterior cingulate , lasso (programming language) , medicine , psychology , alzheimer's disease , computer science , radiology , neuroscience , disease , functional magnetic resonance imaging , world wide web
Background: The Alzheimer’s Disease Neuroimaging Initiative (ADNI) PET Core has analyzed FDG images using ROI and voxel-based approaches.We compare longitudinal effect sizes for these methodologies along with Freesurfer ROI approaches using the same ADNI datasets for each method. Methods:Baseline and 24-m followup data from 399 ADNI subjects (157 Normal, 204 MCI, 32 AD) were included. All subjects also had Florbetapir scans for classification of Ab status. Indices of cortical hypometabolism were computed using five different methods: 1) SPM “MetaROI” , 2) Statistical ROI (sROI) , 3) Longitudinal Hypermetabolic Convergence Index (L-HCI) , 4) Freesurfer nativespace ROI (FS-WB), 5) LASSO-optimized Freesurfer ROI (LASSO-FS-WB). Methods 1-3 have been described previously. Methods 4 and 5 used a Freesurfer MRI segmentation to obtain SUVR indices from co-registered PET data. Both Freesurfer methods used a whole brain reference region and target regions known to be affected by AD, including the cingulate, precuneus, temporal, hippocampal and parietal areas. Longitudinal Cohen’s effect size was evaluated for each method, stratifying by “persons at increased risk for decline” defined as baseline Ab+ Normals, Ab+ MCIs, and Ab+ ADs compared to a “non-decliner” group defined as baseline AbNormals. Results: All analysis methods show increasing absolute longitudinal difference and effect sizes for the Ab+ Normals, Ab+ MCIs, and Ab+ AD decliner groups respectively compared to the AbNormals. The L-HCI showed the highest effect size (1.8) for the Ab+ Ads followed by the LASSO-FS-WB, sROI, FS-WB and MetaROI methods respectively. Conclusions:Though the MetaRoi method shows the greatest longitudinal difference, it actually has the smallest effect size of all methods. Reduced sample size in clinical trials may be possible using alternate methods. 1. Jagust, et al. Alz&Dementia 6 (2010):221-229. 2. Landau, et al. Neurology 2010;75:230-238 3. Chen, et al. Neuroimage 2010;51(2):654-664. 4. Chen, et al. HAI 2016. PO-49, p 151.