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P1‐249: The Association Between Aβ and TAU Accumulations and Its Influence on Clinical Features in Aging and Alzheimer’s Disease Spectrum Brains: [ 11 C]PBB3 PET Study
Author(s) -
Shimada Hitoshi,
Suhara Tetsuya,
Shinotoh Hitoshi,
Endo Hironobu,
Niwa Fumitoshi,
Kitamura Soichiro,
Hirano Shigeki,
Kimura Yasuyuki,
Yamada Makiko,
Sahara Naruhiko,
Zhang Ming-Rong,
Kuwabara Satoshi,
Higuchi Makoto
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.998
Subject(s) - pittsburgh compound b , positron emission tomography , standardized uptake value , tauopathy , neuroimaging , alzheimer's disease , pathology , hippocampus , psychology , senile plaques , medicine , neuroscience , disease , neurodegeneration
ter. CVR in the region of WMH 0.1460.15%; significantly (p<0.001) lower than normal appearing white matter. CVR was significantly positively correlated with CBF (Figure 2a, r1⁄40.46, p1⁄40.006) and MMSE (r1⁄40.48, p1⁄40.004). While only marginally significant, magnitude of CVR was negatively correlated with WMH burden (r1⁄4-0.27, p1⁄40.07). Importantly, while negative CVR was not significantly correlated with other measures, total voxels with negative CVR (indicative of vascular pathology spread, excluding CSF) was significantly correlated with MMSE (Figure 2b, r1⁄4-0.69, p<0.001). Conclusions: We have demonstrated the feasibility of a simple breath-hold BOLD MRI paradigm to evaluate CVR and its association with other vascular factors as well as cognition.