P1‐247: Network‐Based TAU Deposition Patterns are Related to Functional Network Failure Largely Via Beta‐Amyloid Across the Alzheimer’s Spectrum | Zendy

Jones David T. | Zendy; Lowe Val J. | Zendy; Wiste Heather J. | Zendy; Senjem Matthew L. | Zendy; Radford Jonathan Graff | Zendy; Boeve Bradley F. | Zendy; Knopman David S. | Zendy; Petersen Ronald C. | Zendy; Jack Clifford R. | Zendy

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P1‐247: Network‐Based TAU Deposition Patterns are Related to Functional Network Failure Largely Via Beta‐Amyloid Across the Alzheimer’s Spectrum

Author(s) -

Jones David T.,

Lowe Val J.,

Wiste Heather J.,

Senjem Matthew L.,

Radford Jonathan Graff,

Boeve Bradley F.,

Knopman David S.,

Petersen Ronald C.,

Jack Clifford R.

Publication year - 2016

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2016.06.996

Subject(s) - neuroscience , psychology , dementia , beta (programming language) , default mode network , amyloid (mycology) , medicine , disease , pathology , cognition , computer science , programming language

Background: The cascading network failure (CNF) model of Alzheimer’s disease (AD) pathophysiology hypothesizes that synaptic activity related to shifts in large-scale functional network organization is causally related to observed beta-amyloid accumulation via alteration in amyloid precursor protein processing. Once the large-scale network reorganization interacts with vulnerable brain systems, a tau-related neurodegenerative process evolves within that system. To test these predications, we investigated the relationship between Tau-PET, task-free fMRI, and beta amyloid-PET in a cross-sectional sample spanning the Alzheimer’s disease spectrum.

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