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P1‐247: Network‐Based TAU Deposition Patterns are Related to Functional Network Failure Largely Via Beta‐Amyloid Across the Alzheimer’s Spectrum
Author(s) -
Jones David T.,
Lowe Val J.,
Wiste Heather J.,
Senjem Matthew L.,
Radford Jonathan Graff,
Boeve Bradley F.,
Knopman David S.,
Petersen Ronald C.,
Jack Clifford R.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.996
Subject(s) - neuroscience , psychology , dementia , beta (programming language) , default mode network , amyloid (mycology) , medicine , disease , pathology , cognition , computer science , programming language
Background: The cascading network failure (CNF) model of Alzheimer’s disease (AD) pathophysiology hypothesizes that synaptic activity related to shifts in large-scale functional network organization is causally related to observed beta-amyloid accumulation via alteration in amyloid precursor protein processing. Once the large-scale network reorganization interacts with vulnerable brain systems, a tau-related neurodegenerative process evolves within that system. To test these predications, we investigated the relationship between Tau-PET, task-free fMRI, and beta amyloid-PET in a cross-sectional sample spanning the Alzheimer’s disease spectrum.