P1‐224: Gender Differences in Behavioral and Psychological Symptoms in Patients with Alzheimer’s Disease | Zendy

Lee Kang Joon | Zendy; Kim Yo Sup | Zendy; Kim Hyun | Zendy; Lee Jeeye | Zendy

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P1‐224: Gender Differences in Behavioral and Psychological Symptoms in Patients with Alzheimer’s Disease

Author(s) -

Lee Kang Joon,

Kim Yo Sup,

Kim Hyun,

Lee Jeeye

Publication year - 2016

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2016.06.973

Subject(s) - dementia , depression (economics) , disease , affect (linguistics) , psychology , alzheimer's disease , activities of daily living , clinical psychology , psychiatry , dysphoria , cognition , cognitive impairment , medicine , anxiety , communication , economics , macroeconomics

longer in AD patients. In structural MRI larger LC volumes were observed for the left LC in the control group compared to AD subjects. Conclusions: Our preliminary results show alterations in behavioral and functional parameters in a signal detection task that are consistent with hypothesis (exception: shorter latency of P300b in AD patients). Our results demand confirmation in a larger sample and a demonstration that the parameters are sensitive to pharmacological manipulations of the NE systems. We suggest that these parameters might be suitable surrogate markers for pharmacological interventions targeting the LC-NE-system in AD.

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