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P1‐224: Gender Differences in Behavioral and Psychological Symptoms in Patients with Alzheimer’s Disease
Author(s) -
Lee Kang Joon,
Kim Yo Sup,
Kim Hyun,
Lee Jeeye
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.973
Subject(s) - dementia , depression (economics) , disease , affect (linguistics) , psychology , alzheimer's disease , activities of daily living , clinical psychology , psychiatry , dysphoria , cognition , cognitive impairment , medicine , anxiety , communication , economics , macroeconomics
longer in AD patients. In structural MRI larger LC volumes were observed for the left LC in the control group compared to AD subjects. Conclusions: Our preliminary results show alterations in behavioral and functional parameters in a signal detection task that are consistent with hypothesis (exception: shorter latency of P300b in AD patients). Our results demand confirmation in a larger sample and a demonstration that the parameters are sensitive to pharmacological manipulations of the NE systems. We suggest that these parameters might be suitable surrogate markers for pharmacological interventions targeting the LC-NE-system in AD.