Premium
P1‐208: a Novel Mutation in the S100A9 Gene Associated with Alzheimer's Disease in a Malaysian Family: Five Cases Report
Author(s) -
Van Giau Vo,
An Seong Soo,
Kim SangYun
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.956
Subject(s) - disease , psen1 , dementia , mutation , family history , exon , genetics , pedigree chart , gene , biology , genetic testing , alzheimer's disease , medicine , presenilin , pathology
justing for age, education, and global cognition revealed group differences for ANY ORDER (p<0.03) and SERIAL ORDER recall (p<0.001). Within-group analyses revealed better SERIAL ORDER recall in the hypothesized direction (NC>aMCI>mMCI, p<0.002) but the NC group only differed from mMCI on ANY ORDER recall (p<0.001). Better SERIAL ORDER recall was associated with larger gray matter volume (p<0.02) and intact white matter volume (p<0.03). Conclusions: Despite equivalent age-corrected scale score performances, our analysis of CQ constructs was able to elucidate more nuanced understanding of visual working memory deficits in MCI. That is, more detailed comparisons suggest mMCI have impairments in both ANY ORDER and SERIAL ORDER processing, suggesting compromised WM performance involving both CQ mechanisms. In aMCI, problemswithWMmay be limited to impaired CQ inhibitory competitive choice/response suppression. Better SERIAL ORDER/competitive choice was associated with larger gray and white matter volume. Future research should better understand the biological underpinnings of CQ mechanisms, including predictive utility of these concepts in cognitive aging.