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P1‐155: Post‐Mortem Brain Tissue Characterisation of Inflammatory and Pathological Hallmarks of Alzheimer’s Disease During Disease Progression
Author(s) -
Hughes Martina M.,
Perez-Nievas Beatriz G.,
Troakes Claire,
Perkinton Michael,
Hanger Diane P.,
Noble Wendy
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.903
Subject(s) - alzheimer's disease , astrocyte , tau protein , synapse , pathological , human brain , pathology , biology , neuroscience , cognitive decline , medicine , central nervous system , disease , dementia
metabolites and signalling pathways associated with mitochondria function. Results: The temporal metabolic profile of brains harvested from 5XFAD mice was significantly different from the metabolic profile of brains harvested from control mice. Expression of metabolic enzymes was reflective of metabolic changes. Signalling pathways associated with mitochondria function were altered in brains of 5XFAD mice compared with control mice. Conclusions: Temporal alterations in brain energy metabolism were found in 5XFAD mice compared to control mice.