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P1‐154: P66SHC Expression Affects The Metabolic State and Amyloid‐β Sensitivity in Neuronal Cells
Author(s) -
Lone Asad,
Cumming Robert C.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.902
Subject(s) - microbiology and biotechnology , neurodegeneration , mitochondrion , biology , oxidative phosphorylation , oxidative stress , extracellular , endogeny , programmed cell death , glycolysis , cytosol , reactive oxygen species , cell culture , anaerobic glycolysis , biochemistry , metabolism , medicine , apoptosis , enzyme , genetics , disease
metabolites and signalling pathways associated with mitochondria function. Results: The temporal metabolic profile of brains harvested from 5XFAD mice was significantly different from the metabolic profile of brains harvested from control mice. Expression of metabolic enzymes was reflective of metabolic changes. Signalling pathways associated with mitochondria function were altered in brains of 5XFAD mice compared with control mice. Conclusions: Temporal alterations in brain energy metabolism were found in 5XFAD mice compared to control mice.