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P1‐097: Rational‐Based Design and Development of Quinazoline‐Based Small‐Molecules: Multi‐Targeting Potential for Alzheimeric Pathologies
Author(s) -
Mohamed Tarek,
Nekkar Rao Praveen P.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.845
Subject(s) - quinazoline , chemistry , rational design , acetylcholinesterase , acetylcholine , small molecule , neuroscience , pharmacology , microbiology and biotechnology , biophysics , biochemistry , enzyme , biology , combinatorial chemistry , genetics
reasoning Mean /SD 13.63 (1.50) 12.38 (1.94) <0.001 0.754 Memory Learning capacity Mean /SD 31.04 (5.36) 28.79 (5.29) <0.001 0.416 Recognition memory Mean /SD 23.14 (1.04) 22.58 (1.47) <0.001 0.474 Working memory Mean /SD 4.35 (0.90) 4.10 (0.86) 0.022 0.272 Verbal long term memory Mean/SD 7.76 (1.86) 7.41 (2.09) 0.135 0.178 Visuospatial function Mean /SD 3.84 (0.36) 3.66 (0.51) <0.001 0.439 Attention Mean /SD 8.57 (2.04) 8.19 (1.77) 0.028 0.261 Visual recognition Mean /SD 9.97 (0.20) 9.92 (0.27) 0.097 0.197 Poster Presentations: Sunday, July 24, 2016 P438